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furanocoumarins
the University of Florida
pummelo
Fred Gmitter
the Journal of the American Society for Horticultural Science
Grapefruits are off-limits for people on certain medications. The tangy fruits contain compounds called furanocoumarins, which can dangerously increase the effective dosage of some blood pressure and heart medications. But scientists at the University of Florida have bred a new type of grapefruit that should enable people on meds to enjoy the fruit without the drug interaction. "There are certain relatives of grapefruit that we call pummelo, some of which are very, very low or have no furanocoumarins in them at all. And we've crossed these with ordinary grapefruit." Fred Gmitter, a citrus geneticist at the University of Florida. These new hybrid grapefruits have even less of the compounds than do other foods that don't get special warnings. "Doctors don't generally tell their patients not to drink lemonade or not to eat celery. So these should be as safe or safer than lemons or celery." The findings are described in the Journal of the American Society for Horticultural Science. The new fruits are also seedless. Which should make them an easy switch for consumers to swallow.
Hybrid Grapefruit Busts Drug Interactions 雜交葡萄柚打破與藥物的互動(dòng) 普通的葡萄柚含有一種物質(zhì)，因此能弱化一些藥效。一種新型雜交品種解決這個(gè)問題。 正在服用某些藥物的患者需要限制食用葡萄柚。這種重口味的水果中含有一種名叫 呋喃并香豆素 的化合物，它對一些作用于 血壓和心臟類 藥物使用的有效劑量會(huì)有嚴(yán)重的影響。 但佛羅里達(dá)大學(xué)的科學(xué)家們已經(jīng)培育出一種新型雜交葡萄柚品種，這樣就可以使得正在進(jìn)行相關(guān)治療的人能夠享用這種水果而不必?fù)?dān)心會(huì)與自己使用的藥物產(chǎn)生沖突作用。 佛羅里達(dá)大學(xué)的柑橘類植物遺傳學(xué)家 Fred Gmitter ：“葡萄柚類水果中有個(gè)品種我們稱之為柚子，其中又有一些品類含有很少甚至不含這類化合物成分。因此我們把這類品種的柚子與普通的葡萄柚進(jìn)行了雜交研究?！?這些新型雜交葡萄柚品種甚至含有比其它植物類食物還要更少的這類化合物，因此更加不用擔(dān)心啦。因?yàn)獒t(yī)生們通常都不會(huì)這樣叮囑患者：“小心飲用檸檬水或者不要吃芹菜”，所以這個(gè)新型雜交品種應(yīng)該和檸檬啊、芹菜之類的食物同樣安全，或更安全呢~ 這項(xiàng)研究結(jié)果已經(jīng)發(fā)表在美國社會(huì)期刊的園藝科學(xué)欄目中。 這種新型水果還是無籽的呢~更方便廣大消費(fèi)者食用了~ —Katherine Harmon ---------------------by hyjtb Special ： Furanocoumarins 或者 furocoumarins （呋喃并香豆素），是一類許多種類的植物中都能產(chǎn)生的有機(jī)化合物，并且大部分都是有毒的。植物是基于抵抗小到昆蟲，大到哺乳類等廣泛的多種類的捕食者而形成的抵抗機(jī)制起作用而產(chǎn)生的這類物質(zhì)[1]。 對于人類，這類物質(zhì)存在的果汁會(huì)對某些化合類藥物的代謝產(chǎn)生影響[2]。 [1] ^ Professor May Berenbaum's research page - University of Illinois at Urbana-Champaign [2] 6′7′-Dihydroxybergamottin Contributes to the Grapefruit Juice Effect*6′7′-Dihydroxybergamottin Contributes to the Grapefruit Juice Effect Pharmacokinetics and Drug Disposition Clinical Pharmacology & Therapeutics 75, 569-579 (June 2004) | doi:10.1016/.2004.02.007